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Another group independently also concluded that disability progression and brain atrophy occur earlier than in the classical secondary progressive stage, with many relapsing patients exhibiting insidious progression without clinical or radiographic evidence of inflammatory disease activity, coining the term silent progression (Cree et al., 2019)

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doi:10.1021/ja00958a026

The 3ml size offers greater flexibility than smaller vials while avoiding unnecessary excess, making it suitable for moderate-duration protocols or multiple reconstitutions